Development and Regeneration

How can a single undifferentiated cell give rise to an entire functional organism? What dictates the shape our bodies take? How can some organisms regenerate large parts of their bodies? Those are some of the fascinating questions tackled by scientists studying the complex interactions comprising development and regeneration.

Here, I review chosen subjects relating to genes and signalling pathways that are central to the field of developmental biology.

The role of histone tail modifications in sequential activation of the Hox gene during early embryo development in mice.
The role of the canonical Wnt/β-catenin pathway in the formation of the dorsal organizer in frog embryo and the development and regeneration of hydra.
"Why don't more organisms have a high regeneration potential?", "Why does retinoic acid treatment result in aberrant limb regeneration?", and other related questions.